GLP-1 RAs are a class of medications used to treat type 2 diabetes. These medications mimic the effects of a naturally occurring hormone called glucagon-like peptide-1 receptor agonist(GLP-1). GLP-1 is released by the gut in response to food, and it helps to regulate blood sugar levels by stimulating insulin secretion and suppressing glucagon production. However, the effects of GLP-1 are short-lived, as the hormone is rapidly broken down by an enzyme called DPP-4. GLP-1 s, on the other hand, are designed to resist breakdown by DPP-4 and remain active in the body for longer periods of time. This leads to a more sustained effect on blood sugar control.
There are several different GLP-1 RAs available on the market, including exenatide, liraglutide, and dulaglutide. These medications can be given by injection once or twice daily, or once weekly, depending on the specific formulation. These drugs have been out for diabetes treatment for a few years, and some patients taking them did see significant weight loss.
The newer injections are even better at weight loss, as they are more designed to fit the receptors, and stay around longer. These are Ozempic (semaglutide), Wegovy (semaglutide higher dose), and Mounjaro (tirzapatide). These drugs help lower blood sugar if you are diabetic and also really help with weight loss if you are not.
A Direct Primary Care doctor can help you with your weight loss goals much easier than having to pay a copay with every visit. We provide the care you need at one affordable monthly rate. More information in the next post!