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How DO the New Weight Loss Shots Work?

By now you have heard a bit about Ozempic/Wegovy and Mounjaro. These GLP-1 RAs work by binding to and activating GLP-1 receptors in various tissues throughout the body, including the pancreas, liver, and brain. When these receptors are activated, several things happen:


1. Insulin secretion: GLP-1 RAs stimulate the pancreas to produce and release more insulin in response to food, which helps to lower blood sugar levels.

2. Glucagon suppression: GLP-1 RAs also suppress the release of glucagon from the pancreas, which normally raises blood sugar levels. By reducing glucagon production, GLP-1 RAs help to keep blood sugar levels in check.

3. Appetite suppression: GLP-1 RAs can also reduce appetite and promote feelings of fullness, which can lead to weight loss in most patients.


Overall, GLP-1 RAs are a highly effective treatment for type 2 diabetes, as they address multiple aspects of the disease and can help patients achieve better blood sugar control and weight management. The two newest to the market show much better results for weight loss even without having diabetes.


A Direct Primary Care doctor can help you with your weight loss goals much easier than having to pay a copay with every visit. We provide the care you need at one affordable monthly rate. More information in the next post!



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