GLP-1 RAs are a class of medications used to treat type 2 diabetes, but they have also been shown to have a positive effect on weight loss. GLP-1 RAs work by binding to and activating GLP-1 receptors in various tissues throughout the body, including the brain, which can help to reduce appetite and promote feelings of fullness. This can lead to a decrease in food intake and an increase in weight loss.
In clinical trials, patients who took GLP-1 RAs experienced an average weight loss of 5-10% of their body weight over several months of treatment. This weight loss was sustained over time and was often accompanied by improvements in other markers of health, such as blood sugar control and cholesterol levels. Wegovy is currently approved for weight loss in the US, and Mounjaro should be getting approval shortly by the FDA for weight loss.
It has been harder to get these medications approved for patients for weight loss. However, for patients who are struggling with weight management in addition to diabetes, GLP-1 RAs can be a helpful addition to their treatment regimen. Often, once you start losing a significant amount of weight, your blood pressure and sugar improve so that you can get off your medications.
In short term studies, patients do tend to regain the weight they lost after stopping the shots, but so far it has been 5-10 pounds on average. You will need to have firm habits and really weigh yourself regularly to maintain your weight loss, or keep taking the shot weekly for an indefinite period of time.
If you are interested in becoming a DPC patient and see if you are eligible for the shot, sign up at wholefamilymedical.com or call Dr. Eleanor Host at 419-872-3250.